The Catechism in Questions & Answers

224. What were the consequences for mankind of the fall into sin?

The fall into sin brought about changes in the lives of human beings, which they could not reverse. They began to be afraid of God and hid themselves from Him. The relationship of human beings toward one another also suffered, as did their relationship with the creation. Since then, the life of man has been filled with toil—and has been limited: “For dust you are, and to dust you shall return” (Genesis 3: 19).
Another consequence of the fall into sin was the separation between mankind and God: God drove the first two human beings from the garden of Eden (cf. Genesis 3: 23-24).

“Therefore the Lord God sent him out of the garden of Eden to till the ground from which he was taken. So He drove out the man; and He placed cherubim at the east of the garden of Eden and a flaming sword which turned every way, to guard the way to the tree of life.”
Genesis 3: 23-24