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The Catechism in Questions & Answers

89. What is associated with the fall into sin?

Separation from God, spiritual death, was the direct consequence of the fall into sin. From then on, human beings had to lead a troubled existence on earth, which would end with physical death (cf. Genesis 3: 16-19).
Since the fall into sin, mankind has been sinful, that is to say, enmeshed in sin and thus incapable of living without sin.

Spiritual death: see Question 532.

“Cursed is the ground for your sake; in toil you shall eat of it all the days of your life. [...] For dust you are, and to dust you shall return.”
Genesis 3: 17, 19